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D Kufe Selected Research

2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid

5/2001The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism.
5/2000The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism.

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D Kufe Research Topics

Disease

15Neoplasms (Cancer)
12/2017 - 03/2000
11Carcinoma (Carcinomatosis)
01/2017 - 03/2000
7Breast Neoplasms (Breast Cancer)
06/2014 - 07/2000
6Myeloid Leukemia (Leukemia, Myelocytic)
12/2001 - 05/2000
2Carcinogenesis
12/2016 - 10/2010
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2017
1Colonic Neoplasms (Colon Cancer)
10/2015
1Acute Promyelocytic Leukemia
05/2005
1Hepatocellular Carcinoma (Hepatoma)
11/2001
1Mitochondrial Diseases (Mitochondrial Disease)
05/2001
1Necrosis
05/2001
1Osteosarcoma (Osteogenic Sarcoma)
05/2001
1Leukemia
08/2000
1Neoplasm Metastasis (Metastasis)
03/2000

Drug/Important Bio-Agent (IBA)

6Mucin-1 (CA 15-3 Antigen)IBA
01/2017 - 03/2001
4Oncogene Proteins (Oncogene Protein)IBA
12/2016 - 02/2010
4Glycoproteins (Glycoprotein)IBA
01/2006 - 02/2001
4AntigensIBA
10/2003 - 03/2000
3Proteins (Proteins, Gene)FDA Link
12/2016 - 04/2013
3Phosphotransferases (Kinase)IBA
10/2015 - 05/2001
3bardoxoloneIBA
05/2005 - 05/2000
3TriterpenesIBA
05/2005 - 05/2000
3Cytochromes c (Cytochrome c)IBA
08/2001 - 08/2000
2Epidermal Growth Factor (EGF)IBA
04/2013 - 09/2001
2Cytarabine (Cytosar-U)FDA LinkGeneric
12/2001 - 05/2000
2Protein Kinases (Protein Kinase)IBA
08/2001 - 12/2000
2oleananeIBA
05/2001 - 05/2000
22-cyano-3,12-dioxoolean-1,9-dien-28-oic acidIBA
05/2001 - 05/2000
2Caspase 3 (Caspase-3)IBA
05/2001 - 08/2000
2Protein Kinase CIBA
12/2000 - 08/2000
1MicroRNAs (MicroRNA)IBA
12/2017
1Immune Checkpoint InhibitorsIBA
01/2017
1Polycomb Repressive Complex 1IBA
01/2017
1B7-H1 AntigenIBA
01/2017
1DNA (Deoxyribonucleic Acid)IBA
12/2016
1MethyltransferasesIBA
12/2016
1TNF Receptor-Associated Factor 6 (TRAF6)IBA
10/2015
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
10/2015
1Trastuzumab (Herceptin)FDA Link
06/2014
1NF-kappa B (NF-kB)IBA
03/2014
1Mechanistic Target of Rapamycin Complex 1IBA
04/2013
1silvestrolIBA
04/2013
1Ribosomal Protein S6 Kinases (S6 Kinase)IBA
04/2013
1TOR Serine-Threonine KinasesIBA
04/2013
1Apoptosis Regulatory ProteinsIBA
04/2013
1RNA Helicases (RNA Helicase)IBA
04/2013
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2009
1ImidesIBA
05/2005
11- (2- cyano- 3,12- dioxooleana- 1,9- dien- 28- oyl) imidazoleIBA
05/2005
1promyelocytic leukemia-retinoic acid receptor alpha fusion oncoproteinIBA
05/2005
1AcidsIBA
05/2005
1IsocoumarinsIBA
11/2001
1Reactive Oxygen Species (Oxygen Radicals)IBA
11/2001
1propionic acid (potassium propionate)IBA
11/2001
1Cyclin-Dependent Kinases (cdk Proteins)IBA
11/2001
1beta CateninIBA
09/2001
1ErbB Receptors (EGF Receptor)IBA
09/2001
1Phorbol EstersIBA
08/2001
1Adenosine Triphosphate (ATP)IBA
05/2001
1OsteocalcinIBA
05/2001
1Caspase 8 (Caspase-8)IBA
05/2001
1Alkaline PhosphataseIBA
05/2001
1Interleukin-12 (IL 12)IBA
11/2000
1RNA (Ribonucleic Acid)IBA
11/2000
1CaspasesIBA
08/2000
1Cytotoxins (Cytolysins)IBA
05/2000

Therapy/Procedure

3Immunotherapy
04/2005 - 08/2000
2Drug Therapy (Chemotherapy)
08/2009 - 07/2000
1Radiotherapy
08/2009
1Aftercare (After-Treatment)
11/2001
1Autologous Transplantation
07/2000